Nalmefene (hydrochloride)
Nalmefene hydrochloride is a long acting opioid (MOR and DOR antagonist), and a partial KOR agonist. Nalmefene hydrochloride is used for opioid overdose and alcohol dependence[1].
Product Specifications
CAS Number
58895-64-0
UNSPSC
12352005
Hazard Statement
H301-H336-H410
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nalmefene-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O[C@]12[C@@]34C5=C(C[C@@]2([H])N(CC4)CC6CC6)C=CC(O)=C5O[C@@]3([H])C(CC1)=C.Cl
Molecular Formula
C21H26ClNO3
Molecular Weight
375.89
Precautions
P261-P264-P270-P271-P273-P304+P340-P330-P391-P403+P233-P405-P501
References & Citations
[1]Mann K, et al. Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacy. Eur Neuropsychopharmacol. 2016 Dec;26 (12) :1941-1949.|[2]Wang DS, et al. Nalmefene: a long-acting opioid antagonist. Clinical applications in emergency medicine. J Emerg Med. 1998 May-Jun;16 (3) :471-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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