Adenosine-13C5

Adenosine-13C5 is the 13C labeled Adenosine[1]. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[2][3].

Product Specifications

CAS Number

[159496-13-6]

Product Name Alternative

Adenine riboside-13C5; D-Adenosine-13C5

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/adenosine-13c5.html

Purity

99.9

Solubility

10 mM in DMSO|DMSO : 33.33mg/mL (ultrasonic) |H2O : ≥ 6.67mg/mL

Smiles

NC1=C(N=CN2[13C@H]3[13C@H](O)[13C@H](O)[13C@@H]([13CH2]O)O3)C2=NC=N1

Molecular Formula

C5 13C5H13N5O4

Molecular Weight

272.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98 (3) :1591-1625.|[3]Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 200714 (7) :1315-1323.|[4]Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 201941 (2) :829-838.|[5]Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009111 (4) :904-915.