Polydatin
Product Specifications
UNSPSC Description
Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
Target Antigen
Apoptosis; Autophagy; Mitophagy
Type
Natural Products
Related Pathways
Apoptosis;Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Polydatin.html
Purity
99.57
Solubility
DMSO : ≥ 29 mg/mL|H2O : 0.1 mg/mL (ultrasonic)
Smiles
O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC(/C=C/C3=CC=C(O)C=C3)=CC(O)=C2
Molecular Weight
390.38
References & Citations
[1]Cheng Y, et al. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion
injury. Brain Res. 2006 Sep 19;1110(1):193-200.|[2]Wang HL, et al. Synergistic effects of Polydatin and Vitamin C in Inhibiting Cardiotoxicity induced by Doxorubicin in rats. Fundam Clin Pharmacol. 2016 Nov 28. [Epub ahead of print]|[3]Jiang KF, et al. Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK/NF-κB pathway. Acta Pharmacol Sin. 2016 Nov 28. [Epub ahead of print]|[4]Luigi Mele, et al. A New Inhibitor of glucose-6-phosphate Dehydrogenase Blocks Pentose Phosphate Pathway and Suppresses Malignant Proliferation and Metastasis in Vivo. Cell Death Dis. 2018 May 1;9(5):572.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0120A/Polydatin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0120A/Polydatin-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
27208-80-6
Available Sizes
Curated Selection
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