Polydatin
Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
Product Specifications
CAS Number
27208-80-6
Product Name Alternative
Piceid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Mitophagy
Type
Natural Products
Related Pathways
Apoptosis; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Polydatin.html
Concentration
10mM
Purity
99.50
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC(/C=C/C3=CC=C(O)C=C3)=CC(O)=C2
Molecular Formula
C20H22O8
Molecular Weight
390.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Cheng Y, et al. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion
 injury. Brain Res. 2006 Sep 19;1110 (1) :193-200.|[2]Wang HL, et al. Synergistic effects of Polydatin and Vitamin C in Inhibiting Cardiotoxicity induced by Doxorubicin in rats. Fundam Clin Pharmacol. 2016 Nov 28. [Epub ahead of print]|[3]Jiang KF, et al. Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK/NF-κB pathway. Acta Pharmacol Sin. 2016 Nov 28. [Epub ahead of print]|[4]Luigi Mele, et al. A New Inhibitor of glucose-6-phosphate Dehydrogenase Blocks Pentose Phosphate Pathway and Suppresses Malignant Proliferation and Metastasis in Vivo. Cell Death Dis. 2018 May 1;9 (5) :572.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 2
Available Sizes
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