Dagrocorat
Dagrocorat (PF-00251802) is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes) . Dagrocorat can be used for the research of rheumatoid arthritis[1].
Product Specifications
CAS Number
1044535-52-5
Product Name Alternative
PF-00251802
UNSPSC
12352005
Target
Cytochrome P450; Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Dagrocorat.html
Purity
99.90
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O[C@@]1(C(F)(F)F)C[C@]2([H])[C@](C3=CC=C(C(NC(C=CC=N4)=C4C)=O)C=C3CC2)(CC1)CC5=CC=CC=C5
Molecular Formula
C29H29F3N2O2
Molecular Weight
494.55
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP2; CYP3
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Olfr1390 CRISPR All-in-one AAV vector set (with saCas9)(Mouse)
NR3C2/Mineralocorticoid receptor Polyclonal Antibody, AbBy Fluor™ 350 Conjugated
MAP Kinase 42 (Mitogen-activated Protein Kinase 1, MAP Kinase 1, MAPK 1, ERT1, Extracellular Signal-regulated Kinase 2, ERK-2, MAP Kinase Isoform p42, p42-MAPK, Mitogen-activated Protein Kinase 2, MAP Kinase 2, MAPK 2, Mapk1, Erk2, Mapk, Prkm1) discontinued
