Skp2 inhibitor 2

Skp2 inhibitor 2 (compound 14ag) is an inhibitor of F-box protein S-phase kinase-associated protein 2 (Skp2), with an IC50 value of 570 nM (Skp2-Cks1) . Skp2 is a part of cullin-RING ligases, which recruits and ubiquitinates substrates, involving in proteolytic and non-proteolytic process[1].

Product Specifications

CAS Number

[2760612-77-7]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/skp2-inhibitor-2.html

Purity

99.88

Solubility

DMSO : 12 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C(C)(C)C)NCC1CCN(CC1)C2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N=C2

Molecular Formula

C27H32N4O

Molecular Weight

428.57

References & Citations

[1]Zhang K, et al. Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Jun 8;66 (11) :7221-7242.