N-Desmethyl clomipramine (hydrochloride)

N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant[1][2].

Product Specifications

CAS Number

[29854-14-6]

Product Name Alternative

Desmethylclomipramine (hydrochloride) ; Norclomipramine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H410

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/n-desmethyl-clomipramine-hydrochloride.html

Purity

99.95

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CNCCCN1C2=CC(Cl)=CC=C2CCC3=CC=CC=C31.[H]Cl

Molecular Formula

C18H22Cl2N2

Molecular Weight

337.29

Precautions

H410

References & Citations

[1]Sioufi A, et al. Simultaneous determination of clomipramine and its N-desmethyl metabolite in human whole blood by capillary gas chromatography with mass-selective detection. J Chromatogr. 1988 Jun 24;428 (1) :71-80.|[2]Härtter S, et al. Non-competitive inhibition of clomipramine N-demethylation by fluvoxamine. Psychopharmacology (Berl) . 1995 Jan;117 (2) :149-53.