EGFR-IN-132
EGFR-IN-132 (Compound 23) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 1.6, 0.025, 0.019, 0.022, and 0.029 nM. EGFR-IN-132 exhibits good pharmacokinetics characteristics with high oral exposure[1].
Product Specifications
CAS Number
[2809982-20-3]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-132.html
Smiles
C[C@H]1CN2C3=CC=C(NC4COC4)C=C3N/C2=N\C(C5=CC(C)=NC(C6=C(N(N=C6)C)OCCC1)=C5)=O
Molecular Formula
C27H31N7O3
Molecular Weight
501.58
References & Citations
[1]Liu F, et al., Macrocyclic compound containing benzoheterocycle and acting as egfr kinase inhibitor, and pharmaceutical composition and use thereof. WO2022166741
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
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