EGFR-IN-132
Product Specifications
UNSPSC Description
EGFR-IN-132 (Compound 23) is an inhibitor for EGFR, that inhibits the EGFR wildtype, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S mutans with IC50 of 1.6, 0.025, 0.019, 0.022, and 0.029 nM. EGFR-IN-132 exhibits good pharmacokinetics characteristics with high oral exposure[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-132.html
Smiles
C[C@H]1CN2C3=CC=C(NC4COC4)C=C3N/C2=N\C(C5=CC(C)=NC(C6=C(N(N=C6)C)OCCC1)=C5)=O
Molecular Weight
501.58
References & Citations
[1]Liu F, et al., Macrocyclic compound containing benzoheterocycle and acting as egfr kinase inhibitor, and pharmaceutical composition and use thereof. WO2022166741
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169308/EGFR-IN-132-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169308/
Clinical Information
No Development Reported
CAS Number
2809982-20-3
Curated Selection
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