SB-657510
SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells[1][2].
Product Specifications
CAS Number
474960-44-6
UNSPSC
12352005
Hazard Statement
H303, H315, H319, H335
Target
Urotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sb-657510.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(C=C1)=C(O[C@H]2CN(C)CC2)C=C1NS(C3=CC(OC)=C(OC)C=C3Br)(=O)=O
Molecular Formula
C19H22BrClN2O5S
Molecular Weight
505.81
Precautions
H303, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
![IGF1 Receptor (IGF1R) Mouse Monoclonal Antibody [Clone ID: OTI11E4]](https://cdn.genprice.uk/products/937/68dd18b9061270361e9081bd/imageurl/cf807836.webp)
IGF1 Receptor (IGF1R) Mouse Monoclonal Antibody [Clone ID: OTI11E4]
![Purified Anti-Human CD172g Antibody[OX-119]](https://cdn.genprice.uk/products/763/68dd14c4061270361e7d7191/imageurl08/an002870p.webp)
