Amantadine (hydrochloride)

Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].

Product Specifications

CAS Number

[665-66-7]

Product Name Alternative

1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bcl-2 Family; CDK; Influenza Virus; Orthopoxvirus; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Amantadine-hydrochloride.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

NC1(C2)C[C@@H]3C[C@@H](C[C@H]2C3)C1.Cl

Molecular Formula

C10H18ClN

Molecular Weight

187.71

Precautions

H302, H315, H319, H335

References & Citations

[1]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9 (3) :195-200.|[2]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78 (14) :1096-1099.|[3]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52. |[4]Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13 (4) :539. |[5]Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121 (4) :773-85. |[6]Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36 (3) :904-910.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature, keep dry and cool

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Bax; Bcl-2; CDK2

Citation 01

Chem Phys Lipids. 2024 May 11:262:105397.|Int J Nanomedicine. 2019 Nov 27;14:9217-9234.|Signal Transduct Target Ther. 2021 Mar 27;6 (1) :134.|ACS Infect Dis. 2025 Jun 13;11 (6) :1437-1447.|Emerg Microbes Infect. 2025 Dec;14 (1) :2564308.|Int J Mol Sci. 2025 Jun 3;26 (11) :5358.|Open Forum Infect Dis. 2025 Apr 10;12 (5) :ofaf212.|SSRN. 2024 Aug 7.|Virol J. 2025 Jun 4;22 (1) :181.