Umifenovir (hydrochloride)

Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3].

Product Specifications

CAS Number

[131707-23-8]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

CHIKV; Influenza Virus; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Arbidol-hydrochloride.html

Concentration

10mM

Purity

99.86

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(CSC2=CC=CC=C2)N(C)C3=C1C(CN(C)C)=C(O)C(Br)=C3)OCC.[H]Cl

Molecular Formula

C22H26BrClN2O3S

Molecular Weight

513.88

Precautions

H315, H319

References & Citations

[1]Boriskin YS, et al. Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem. 2008;15 (10) :997-1005.|[2]Liu Q, et al. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacol Sin. 2013;34 (8) :1075-1083.|[3]Wang X, et al. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020;6:28. Published 2020 May 2.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

BioRxiv. 2020 Mar.|Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.|mBio. 2021 Feb 22;13 (1) :e0304421.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Signal Transduct Target Ther. 2021 Apr 24;6 (1) :165.|Viruses. 2019 Jul 20;11 (7) :665.|Viruses. 2021 Jul 23;13 (8) :1433.|Adv Sci (Weinh) . 2025 Oct 6:e10597.|J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2501743.|SSRN. 2024 Jan 26.