P18IN005 (hydrochloride)
P18IN005 hydrochloride is a novel inhibitor of p18, exhibiting potent activity in negatively regulating haematopoietic stem cell (HSC) self-renewal. P18IN005 hydrochloride has been shown to be more effective than p27 in inhibiting HSC self-renewal in mouse models. P18IN005 hydrochloride promotes the expansion of functional HSCs in short-term cultures. P18IN005 hydrochloride serves as a valuable tool for dissecting the signaling pathways involved in stem cell self-renewal.
Product Specifications
CAS Number
7403-44-3
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p18in005-hydrochloride.html
Smiles
COC1=CC=C(C=C1)C(C(C2=CC=CC=C2)NCCCC)=O.Cl
Molecular Formula
C19H24ClNO2
Molecular Weight
333.85
References & Citations
[1]Small-molecule inhibitors targeting INK4 protein p18 (INK4C) enhance ex vivo expansion of haematopoietic stem cells
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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