Beta-Mangostin

Beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) [1][2][3][4].

Product Specifications

CAS Number

[20931-37-7]

Product Name Alternative

β-Mangostin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bacterial; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/beta-Mangostin.html

Purity

99.84

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

C1(=O)C2=C(C=C(O)C(OC)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(OC)=C2

Molecular Formula

C25H28O6

Molecular Weight

424.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Chien-Feng Huang, et al.β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways. Environ Toxicol. 2017 Nov;32 (11) :2360-2370.|[2]Fatima Abdelmutaal Ahmed Omer, et al. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G 0/G 1 cell-cycle arrest. Tumour Biol. 2017 Nov;39 (11) :1010428317731451.|[3]K Likhitwitayawuid, et al. Antimalarial xanthones from Garcinia cowa. Planta Med. 1998 Feb;64 (1) :70-2.|[4]Sunit Suksamrarn, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo) . 2003 Jul;51 (7) :857-9.