A-836339
A-836339 is a selective CB2 receptor agonist, with Ki values of 0.4 nM and 0.8 nM in humans and rats, respectively. A-836339 exhibits multiple effects such as analgesia, gastric protection, anti-inflammation, and antioxidant activity. A-836339 produces antinociceptive and analgesic activities by activating CB2 receptors in the dorsal root ganglia and spinal cord. A-836339 can also exert gastric protective effects through anti-inflammatory mechanisms (reducing TNF-α and IL-1β) and antioxidant mechanisms (enhancing the activities of CAT and SOD, and reducing H2O2) . Radioactively labeled A-836339 can serve as a CB2-specific radioligand for autoradiography and PET imaging. A-836339 can be used in research on inflammatory pain, neuropathic pain, gastric ulcers, cerebral ischemia, etc[1][2][3][4][5].
Product Specifications
CAS Number
[959746-77-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease; Others
Assay Protocol
https://www.medchemexpress.com/A-836339.html
Purity
99.84
Solubility
DMSO : 12 mg/mL (ultrasonic; warming)
Smiles
CC1=C(C)S/C(N1CCOC)=N\C(C2C(C)(C)C2(C)C)=O
Molecular Formula
C16H26N2O2S
Molecular Weight
310.45
Precautions
H302, H315, H319, H335
References & Citations
11
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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