N1-Acetylspermidine (hydrochloride)

N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO) . N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research[1][2][3][4][5].

Product Specifications

CAS Number

[34450-16-3]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n1-acetylspermidine-hydrochloride.html

Concentration

10mM

Purity

99.13

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

CC(NCCCNCCCCN)=O.[H]Cl.[H]Cl

Molecular Formula

C9H23Cl2N3O

Molecular Weight

260.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1, N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44 (18) :7079-84.|[2]Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA.|[3]Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44 (2) :845-7.|[4]Kato M, et al. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS Nexus. 2023 Oct 10;2 (10) :pgad306.|[5]Gossé F, et al. Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. Int J Oncol. 2006 Aug;29 (2) :423-8.