8- (3-Chlorostyryl) caffeine
8- (3-Chlorostyryl) caffeine (CSC) is an adenosine antagonist with selective activity at the A2a adenosine receptor. 8- (3-Chlorostyryl) caffeine showed 520-fold selectivity in radioligand binding experiments in rat brain. Antagonism of adenylylase by 8- (3-Chlorostyryl) caffeine shows 22-fold selectivity in rat chromaffin cells When 8- (3-Chlorostyryl) caffeine is co-administered with the A1-selective antagonist CPX, It can also further increase exercise activity. 8- (3-Chlorostyryl) caffeine exhibits good MAO-B inhibitory activity in primate mitochondria. 8- (3-Chlorostyryl) caffeine also has excellent A2A receptor affinity[1].
Product Specifications
CAS Number
148589-13-3
Product Name Alternative
CSC
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/8-3-chlorostyryl-caffeine.html
Smiles
O=C(N(C1=C(C2=O)N(C(/C=C/C3=CC=CC(Cl)=C3)=N1)C)C)N2C
Molecular Formula
C16H15ClN4O2
Molecular Weight
330.77
References & Citations
[1]8- (3-Chlorostyryl) caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4
Frequently Asked Questions
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