IRAK4-IN-22
Product Specifications
UNSPSC Description
IRAK4-IN-22 (compound 18) is an orally active, potent and selective IRAK4 inhibitor with IC50 values of 3 and 17 nM for IRAK4 and TAK1, respectively. IRAK4-IN-21 effectively inhibits IL-23 production (IC50=0.10 μM) and can be used in studies of autoimmune diseases such as plaque psoriasis and psoriatic arthritis[1].
Target Antigen
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/irak4-in-22.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1[C@@H](C2)C=C[C@@H]2[C@H]1NC3=NC(NC4=CC=CC(C(N5CCCC5)=O)=C4)=NC=C3C6=CC(F)=NC=C6)N
Molecular Weight
513.57
References & Citations
[1]Chen Y, et al. Discovery of 5-Aryl-2,4-diaminopyrimidine Compounds as Potent and Selective IRAK4 Inhibitors. ACS Med Chem Lett. 2022 Apr 4;13(4):714-719.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151365/IRAK4-IN-22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151365/IRAK4-IN-22-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2170694-05-8
Available Sizes
Curated Selection
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