(-) SHIN2
(-) SHIN2 is the isomer of (+) SHIN2. (+) SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+) SHIN2 synergisty with and Methotrexate (HY-14519) in vivo xenotransplantation models[1]. (-) SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
UNSPSC
12352005
Target
SHMT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/minus-shin2.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC([C@]1(C2=CC(C#CCCCO)=CC(CO)=C2)C(C)C)=C(N)OC3=C1C(C)=NN3
Molecular Formula
C23H26N4O3
Molecular Weight
406.48
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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