JS11
JS11 is an inhibitor for natriuretic polypeptide receptor 1 (Npr1) with an IC50 of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models[1].
Product Specifications
CAS Number
[1394592-04-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Natriuretic Peptide Receptor (NPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/js11.html
Purity
99.22
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=CC=C2C(N(CC3CC3)C(N2C4CCCCC4)=O)=C1)NCC5=CC(C)=NO5
Molecular Formula
C23H28N4O3
Molecular Weight
408.49
Precautions
H302, H315, H319
References & Citations
[1]Hoon MA, et al., Compositions and methods for the inhibition of pruritus. WO2019090039.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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