Pimavanserin
Product Specifications
UNSPSC Description
Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
Target Antigen
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pimavanserin.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)COC1=CC=C(CNC(N(CC2=CC=C(F)C=C2)C3CCN(C)CC3)=O)C=C1
Molecular Weight
427.55
References & Citations
[1]Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.|[2]Vanover KE, et al. A 5-HT2A receptor inverse agonist, ACP-103, reduces tremor in a rat model and levodopa-induced dyskinesias in a monkey model. Pharmacol Biochem Behav. 2008 Oct;90(4):540-4.ACS Chem Neurosci. 2019 Nov 20;10(11):4476-4491. |bioRxiv. 2020 Feb.|Department Neuroscience. Virginia Commonwealth University. 2016 Oct.|Int J Clin Exp Med. 2019;12(8):10342-10349|Int J Neuropsychopharmacol. 2021 Jul 6;pyab040.|J Med Chem. 2023 Jun 28.|Patent. US20200352950A1.|Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26438-26447.|Sci Rep. 2024 Jan 16;14(1):1396.|bioRxiv. 2023 Jul 31.|Food Chem Toxicol. 2023 Apr 24;113800.|Nat Commun. 2023 Dec 15;14(1):8221.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14557/Pimavanserin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14557/Pimavanserin-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
706779-91-1
Available Sizes
Curated Selection
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