Propacetamol (hydrochloride)

Propacetamol hydrochloride is an analgesic agent, can be used in induction of acute liver injury. Propacetamol hydrochloride acts function through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress. Propacetamol hydrochloride also is a precursor form of paracetamol. Propacetamol hydrochloride can be used in postoperative pain, acute trauma and gastrointestinal disorders[1].

Product Specifications

CAS Number

[66532-86-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/propacetamol-hydrochloride.html

Purity

99.89

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 250 mg/mL (ultrasonic)

Smiles

O=C(OC1=CC=C(NC(C)=O)C=C1)CN(CC)CC.[H]Cl

Molecular Formula

C14H21ClN2O3

Molecular Weight

300.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Ewan D McNicol, et al. Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain. Cochrane Database Syst Rev.|[2]Tsai MS, et al. Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice. Toxicol Lett. 2018 Jun 15;290:97-109.