Chromium picolinate

Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes[1][2][3][4].

Product Specifications

CAS Number

[14639-25-9]

Product Name Alternative

Chromium (III) picolinate; Cr (Pic) 3

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; p38 MAPK

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/chromium-picolinate.html

Purity

99.76

Solubility

DMSO : 7.81 mg/mL (ultrasonic)

Smiles

O=C1[O-][Cr+3]([N]2=C(C=CC=C2)C3=O)([O-]3)([N]4=C(C=CC=C4)C5=O)([O-]5)[N]6=C1C=CC=C6

Molecular Formula

C18H12CrN3O6

Molecular Weight

418.30

Precautions

H302

References & Citations

[1]Jana M, et al. Chromium picolinate induced apoptosis of lymphocytes and the signaling mechanisms thereof. Toxicol Appl Pharmacol. 2009 Jun 15;237 (3) :331-44.|[2]Wang YQ, et al. Effects of chromium picolinate on glucose uptake in insulin-resistant 3T3-L1 adipocytes involve activation of p38 MAPK. J Nutr Biochem. 2009 Dec;20 (12) :982-91.|[3]Kim DS, et al. Chromium picolinate supplementation improves insulin sensitivity in Goto-Kakizaki diabetic rats. J Trace Elem Med Biol. 2004;17 (4) :243-7.|[4]Sundaram B, et al. Chromium picolinate attenuates hyperglycemia-induced oxidative stress in streptozotocin-induced diabetic rats. J Trace Elem Med Biol. 2013 Apr;27 (2) :117-21.