Mebeverine (hydrochloride)
Mebeverine hydrochloride, a β-phenylethylamine derivative, is a musculotropic agent that potently blocks intestinal peristalsis. Mebeverine directly blocks voltage-operated sodium channels and inhibits intracellular calcium accumulation[1][2].
Product Specifications
CAS Number
2753-45-9
UNSPSC
12352005
Hazard Statement
H302
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Mebeverine_hydrochloride.html
Purity
99.85
Solubility
DMSO : ≥ 155 mg/mL
Smiles
O=C(OCCCCN(CC)C(C)CC1=CC=C(OC)C=C1)C2=CC=C(OC)C(OC)=C2.[H]Cl
Molecular Formula
C25H36ClNO5
Molecular Weight
466.01
Precautions
H302
References & Citations
[1]Den Hertog A, et al. Modification of alpha 1-receptor-operated channels by mebeverine in smooth muscle cells of guinea-pig taenia caeci. Eur J Pharmacol. 1987 Jun 26;138 (3) :367-74.|[2]Annaházi A, et al. Role of antispasmodics in the treatment of irritable bowel syndrome. World J Gastroenterol. 2014;20 (20) :6031-6043.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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