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Mebeverine (hydrochloride)

Mebeverine hydrochloride, a β-phenylethylamine derivative, is a musculotropic agent that potently blocks intestinal peristalsis. Mebeverine directly blocks voltage-operated sodium channels and inhibits intracellular calcium accumulation[1][2].

Product Specifications

CAS Number

2753-45-9

UNSPSC

12352005

Hazard Statement

H302

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Mebeverine_hydrochloride.html

Purity

99.85

Solubility

DMSO : ≥ 155 mg/mL

Smiles

O=C(OCCCCN(CC)C(C)CC1=CC=C(OC)C=C1)C2=CC=C(OC)C(OC)=C2.[H]Cl

Molecular Formula

C25H36ClNO5

Molecular Weight

466.01

Precautions

H302

References & Citations

[1]Den Hertog A, et al. Modification of alpha 1-receptor-operated channels by mebeverine in smooth muscle cells of guinea-pig taenia caeci. Eur J Pharmacol. 1987 Jun 26;138 (3) :367-74.|[2]Annaházi A, et al. Role of antispasmodics in the treatment of irritable bowel syndrome. World J Gastroenterol. 2014;20 (20) :6031-6043.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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