Calindol (hydrochloride)

Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM[1].

Product Specifications

CAS Number

[729610-18-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CaSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/calindol-hydrochloride.html

Purity

99.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](NCC1=CC2=CC=CC=C2N1)C3=C4C=CC=CC4=CC=C3.Cl

Molecular Formula

C21H21ClN2

Molecular Weight

336.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Lionel Kiefer, et al. Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists. Bioorg Med Chem. 2016 Feb 15;24 (4) :554-69. |[2]Albane Kessler, et al. N2-benzyl-N1- (1- (1-naphthyl) ethyl) -3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. Bioorg Med Chem Lett. 2004 Jun 21;14 (12) :3345-9.|[3]Harry Z E Greenberg, et al. The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca2+ channels. Eur J Pharmacol. 2016 Nov 15;791:659-668.