IP7e

IP7e is a potent, brain-penetrant and orally active Nurr1 activator with an EC50 value of 3.9 nM[1].

Product Specifications

CAS Number

[500164-74-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Nuclear Hormone Receptor 4A/NR4A

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ip7e.html

Purity

99.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C=C(C3=CC=C(COCCOC)C=C3)N1C)ON=C2C4=CC=CC=C4

Molecular Formula

C23H22N2O4

Molecular Weight

390.43

Precautions

H315, H319, H335

References & Citations

[1]Samuel Hintermann, et al. Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg Med Chem Lett. 2007 Jan 1;17 (1) :193-6.|[2]Francesca Montarolo, et al. Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One. 2014 Sep 29;9 (9) :e108791.