TNP-470

TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.

Product Specifications

CAS Number

[129298-91-5]

Product Name Alternative

AGM-1470

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aminopeptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/TNP-470.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@]1([C@@H](C/C=C(C)/C)O1)[C@]([C@@H]2OC)([H])[C@]3(CC[C@H]2OC(NC(CCl)=O)=O)CO3

Molecular Formula

C19H28ClNO6

Molecular Weight

401.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Kidoikhammouan S, et al. TNP-470, a methionine aminopeptidase-2 inhibitor, inhibits cell proliferation, migration and invasion of human cholangiocarcinoma cells in vitro. Asian Pac J Cancer Prev. 2012;13 Suppl:155-60.|[2]White HM, et al. The angiogenic inhibitor TNP-470 decreases caloric intake and weight gain in high-fat fed mice. Obesity (Silver Spring) . 2012 Oct;20 (10) :2003-9.