TNP-470
TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.
Product Specifications
CAS Number
129298-91-5
Product Name Alternative
AGM-1470
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aminopeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/TNP-470.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@]1([C@@H](C/C=C(C)/C)O1)[C@]([C@@H]2OC)([H])[C@]3(CC[C@H]2OC(NC(CCl)=O)=O)CO3
Molecular Formula
C19H28ClNO6
Molecular Weight
401.88
Precautions
H302, H315, H319, H335
References & Citations
[1]Kidoikhammouan S, et al. TNP-470, a methionine aminopeptidase-2 inhibitor, inhibits cell proliferation, migration and invasion of human cholangiocarcinoma cells in vitro. Asian Pac J Cancer Prev. 2012;13 Suppl:155-60.|[2]White HM, et al. The angiogenic inhibitor TNP-470 decreases caloric intake and weight gain in high-fat fed mice. Obesity (Silver Spring) . 2012 Oct;20 (10) :2003-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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