SH-42

SH-42 is a potent and selective inhibitor of human Δ24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice[1].

Product Specifications

CAS Number

[2143952-36-5]

UNSPSC

12352211

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sh-42.html

Purity

99.87

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]12[C@]3([H])C([C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)COC=O)C)=CC[C@@]1([H])C[C@H](CC2)OC(C)=O

Molecular Formula

C25H38O4

Molecular Weight

402.57

References & Citations

[1]Müller C, et, al. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur J Med Chem. 2017 Nov 10;140:305-320.|[2]Desirée Heerdegen, et al. Synthesis of Seco-Analogues of the DHCR24 Inhibitor SH-42. Chemistry europe. 05 September 2020