SH-42
SH-42 is a potent and selective inhibitor of human Δ24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice[1].
Product Specifications
CAS Number
2143952-36-5
UNSPSC
12352211
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sh-42.html
Purity
99.87
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@]12[C@]3([H])C([C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)COC=O)C)=CC[C@@]1([H])C[C@H](CC2)OC(C)=O
Molecular Formula
C25H38O4
Molecular Weight
402.57
References & Citations
[1]Müller C, et, al. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur J Med Chem. 2017 Nov 10;140:305-320.|[2]Desirée Heerdegen, et al. Synthesis of Seco-Analogues of the DHCR24 Inhibitor SH-42. Chemistry europe. 05 September 2020
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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