AT7867 (dihydrochloride)

AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.

Product Specifications

CAS Number

[1431697-86-7]

UNSPSC

12352005

Target

Akt; PKA; Ribosomal S6 Kinase (RSK)

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AT7867-dihydrochloride.html

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 2.27 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=CNN=C4.[H]Cl.[H]Cl

Molecular Formula

C20H22Cl3N3

Molecular Weight

410.77

References & Citations

[1]Grimshaw KM, et al. AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol Cancer Ther, 2010, 9 (5), 1100-1110.