AS1269574
AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes[1][2].
Product Specifications
CAS Number
330981-72-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GPR119; TRP Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/as1269574.html
Purity
99.84
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OCCNC1=NC(C2=CC=C(Br)C=C2)=NC(C)=C1
Molecular Formula
C13H14BrN3O
Molecular Weight
308.17
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPA1
Available Sizes
Frequently Asked Questions
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