AS1269574

AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes[1][2].

Product Specifications

CAS Number

[330981-72-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GPR119; TRP Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/as1269574.html

Purity

99.84

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OCCNC1=NC(C2=CC=C(Br)C=C2)=NC(C)=C1

Molecular Formula

C13H14BrN3O

Molecular Weight

308.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Yoshida S, et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 2010;400 (3) :437-441.|[2]Chepurny OG, et al. GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion. Mol Endocrinol. 2016;30 (6) :614-629.