SKF-83566
SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM) [1][3]. SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM[2]. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta[4]. SKF-83566 can be used for research of parkinson’s disease and nicotine craving alleviation[5].
Product Specifications
CAS Number
99295-33-7
UNSPSC
12352005
Target
5-HT Receptor; Adenylate Cyclase; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/skf-83566.html
Purity
99.86
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
OC1=C(Br)C=C2CCN(C)CC(C3=CC=CC=C3)C2=C1
Molecular Formula
C17H18BrNO
Molecular Weight
332.23
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor; D5 Receptor; α-1 microglobulin
Available Sizes
Frequently Asked Questions
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