Larazotide (acetate)

Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection.

Product Specifications

CAS Number

[881851-50-9]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Gap Junction Protein

Type

Peptides

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Larazotide_acetate.html

Purity

99.68

Solubility

DMSO : 3.2 mg/mL (ultrasonic; warming) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

O=C([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)=O)N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(NCC(O)=O)=O)=O.CC(O)=O

Molecular Formula

C34H59N9O12

Molecular Weight

785.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Di Micco S, et al. Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. Int J Mol Sci. 2021 Aug 30;22 (17) :9427.|[2]Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35 (1) :86-94.