Famotidine

Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

Product Specifications

CAS Number

[76824-35-6]

Product Name Alternative

MK-208

UNSPSC

12352005

Hazard Statement

H303, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Endocrinology; Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Famotidine.html

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

Smiles

N=C(NS(=O)(N)=O)CCSCC1=CSC(NC(N)=N)=N1

Molecular Formula

C8H15N7O2S3

Molecular Weight

337.45

Precautions

H303, H315, H319, H335

References & Citations

[1]Inan, A., et al., Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo), 2009. 64 (6) : p. 567-70.|[2]Miyata, K., et al., Studies on the mechanism for the gastric mucosal protection by famotidine in rats. Jpn J Pharmacol, 1991. 55 (2) : p. 211-22.