Ubavitinib
AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. AZD3229 inhibits c-KIT with an IC50 value of 223.3 nM[1][2].
Product Specifications
CAS Number
2248003-60-1
Product Name Alternative
AZD3229
UNSPSC
12352005
Target
C-Kit
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD3229.html
Purity
99.69
Solubility
DMSO : 40 mg/mL (ultrasonic)
Smiles
COCCOC1=CC(F)=C2C(N=CN=C2NC3=CC=C(NC(CN4C=C(C(C)C)N=N4)=O)C=C3)=C1
Molecular Formula
C24H26FN7O3
Molecular Weight
479.51
References & Citations
[1]Kettle JG, et al. Discovery of N- (4-{[5-Fluoro-7- (2-methoxyethoxy) quinazolin-4-yl]amino} phenyl) -2-[4- (propan-2-yl) -1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors. J Med Chem. 2018 Oct 11;61 (19) :8797-8810.|[2]Ryu H, et.al. Antitumor Activity of a Novel Tyrosine Kinase Inhibitor AIU2001 Due to Abrogation of the DNA Damage Repair in Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2019 Sep 24;20 (19) :4728.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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