Org-12962

Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively[1][3].Org-12962 displays antiaversive effects in a rat model of panic-like anxiety[2].

Product Specifications

CAS Number

[132834-56-1]

Product Name Alternative

SR-202

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/org-12962.html

Purity

99.93

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

FC(F)(F)C1=C(N=C(C=C1)N2CCNCC2)Cl

Molecular Formula

C10H11ClF3N3

Molecular Weight

265.66

Precautions

H301, H311, H331

References & Citations

[1]Porter RH, et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128 (1) :13-20.|[2]Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8 (3) :161-8.|[3]Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263 (1-2) :113-22.