(1R) -AZD-1480
(1R) -AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor[1].
Product Specifications
CAS Number
[935666-99-2]
UNSPSC
12352005
Hazard Statement
H302
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1r-azd-1480.html
Purity
97.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(N=C(N=C1)N[C@H](C)C2=NC=C(C=N2)F)NC3=NNC(C)=C3
Molecular Formula
C14H14ClFN8
Molecular Weight
348.77
Precautions
H302
References & Citations
[1]Derenzini E, et al. The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma. Blood Cancer J. 2011 Dec;1 (12) :e46.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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