Tenidap-d3
Tenidap-d3 is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor[3].
Product Specifications
CAS Number
142741-60-4
Product Name Alternative
CP-66248-d3
UNSPSC
12352005
Target
COX
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O/C(C1=C([2H])C([2H])=C([2H])S1)=C2C3=C(C=CC(Cl)=C3)N(C(N)=O)C/2=O
Molecular Formula
C14H6D3ClN2O3S
Molecular Weight
323.77
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282 (2) :1094-101.|[3]Blackburn WD Jr, et al. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis Rheum. 1995 Oct;38 (10) :1447-56.|[4]Julio C Chávez, et al. Participation of the Cl-/HCO (3) - exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol Reprod. 2012 Jan 19;86 (1) :1-14.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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