Pseudoisocyanine (iodide)

Pseudoisocyanine iodide (1,1'-Diethyl-2,2'-cyanine iodide) is an inhibitor of organic cation transporters (OCT1, OCT2, OCT3) and plasma membrane monoamine transporter (PMAT) . Pseudoisocyanine iodide has antidepressant activity[1][2].

Product Specifications

CAS Number

[977-96-8]

Product Name Alternative

1,1'-Diethyl-2,2'-cyanine iodide; Decynium 22; Diethylcyanine iodide; Eastman 7851

UNSPSC

12352005

Hazard Statement

H300+H330, H312, H315, H319, H335

Target

Monoamine Transporter; Serotonin Transporter

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pseudoisocyanine-iodide.html

Purity

99.97

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CCN1C2=CC=CC=C2C=C/C1=C\C3=[N+](C4=CC=CC=C4C=C3)CC.[I-]

Molecular Formula

C23H23IN2

Molecular Weight

454.35

Precautions

H300+H330, H312, H315, H319, H335

References & Citations

[1]Fraser-Spears R, et al. Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter. Eur J Pharmacol. 2019 Jan 5;842:351-364.|[2]Horton RE, et al. Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression. J Neurosci. 2013 Jun 19;33 (25) :10534-43.