KRAS G12C inhibitor 67
KRAS G12C inhibitor 67 (example 35) is a KRAS G12C inhibitor that selectively inhibits the growth of many KRAS G12C mutant tumor cell lines[1].
Product Specifications
CAS Number
[2649788-46-3]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12c-inhibitor-67.html
Concentration
10mM
Purity
98.80
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
N#CC1=C(N)SC2=C(F)C=CC(C3=C(F)C=C(C(N4[C@@](CN(CC4)C(C=C)=O)([H])CCO5)=O)C5=C3Cl)=C12
Molecular Formula
C25H19ClF2N4O3S
Molecular Weight
528.96
References & Citations
[1]Serge Louis Boulet, et al. Kras g12c inhibitors. WO2021118877A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
Curated Selection
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