PRMT5-IN-33
PRMT5-IN-33 (compound A8) is a selective, SAM-competitve PRMT5 inhibitors with IC50 of 10.9 nM. PRMT5-IN-33 induces apoptosis and inhibits proliferation of cells Z-138 and MOLM-13. PRMT5-IN-33 exhibits an antitumor activity[1].
Product Specifications
CAS Number
3054228-62-2
UNSPSC
12352005
Target
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prmt5-in-33.html
Solubility
10 mM in DMSO
Smiles
BrC1=CC2=CC=C(C=C2N=C1N)CC[C@@H]3[C@H]([C@H]([C@@H](C3)NC4=C(C=NC=N4)C(C5=CSC=C5)=O)O)O
Molecular Formula
C25H24BrN5O3S
Molecular Weight
554.46
References & Citations
[1]Chen Y, et al., Structure-based discovery of a new series of nucleoside-derived ring-opening PRMT5 inhibitors. Eur J Med Chem. 2024 Jan 28;267:116171.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT1; PRMT5
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