Apolipoprotein M/APOM, Human (HEK293, His)

Apolipoprotein M Protein, Human (HEK293, His) expresses in HEK293 with a His tag at the N-terminus. Apolipoprotein E (apoE) secreted by HEK cells stably expressing apoE3 or apoE4 (HEK-apoE) binds Aβ, and inhibits Aβ-induced neurotoxicity [1]. The signal peptide is not cleaved and is required for ApoM association with lipoprotein particles as well as Megalin mediated reabsorption by the kidney. ApoM is cleared from the circulation by the ubiquitously expressed LDL R.

CPEHSQLTTL GVDGKEFPEV HLGQWYFIAG AAPTKEELAT FDPVDNIVFN MAAGSAPMQL HLRATIRMKD GLCVPRKWIY HLTEGSTDLR TEGRPDMKTE LFSSSCPGGI MLNETGQGYQ RFLLYNRSPH PPEKCVEEFK SLTSCLDSKA FLLTPRNQEA CELSNN

[1]LaDu MJ, et al. Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein. Biochemistry. 2006 Jan 17;45(2):381-90.