Cytochalasin B

Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with Kd value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.

Product Specifications

CAS Number

[14930-96-2]

Product Name Alternative

Phomin

UNSPSC

12352005

Hazard Statement

H300+H310+H330, H361

Target

Arp2/3 Complex

Type

Natural Products

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Cytochalasin_B.html

Purity

99.84

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 25 mg/mL (ultrasonic)

Smiles

O=C1N[C@@H](CC2=CC=CC=C2)[C@@]3([H])[C@]14[C@](/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C(O4)=O)([H])[C@H](O)C([C@H]3C)=C

Molecular Formula

C29H37NO5

Molecular Weight

479.61

Precautions

H300+H310+H330, H361

References & Citations

[1]Theodoropoulos PA, et al. Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping. Biochem Pharmacol. 1994 May 18;47 (10) :1875-81.|[2]Trendowski M, et al. Chemotherapy with cytochalasin congeners in vitro and in vivo against murine models. Invest New Drugs. 2015 Apr;33 (2) :290-9.|[3]Zhou C, et al. The effect of Cytochalasin B and Jasplakinolide on depolymerization of actin filaments in goose muscles during postmortem conditioning. Food Res Int. 2016 Dec;90:1-7.|[4]Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25 (1) :24-38.