Didemnin B

Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer[1].

Product Specifications

CAS Number

[77327-05-0]

UNSPSC

12352209

Hazard Statement

H319, H400, H410

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/didemnin-b.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC([C@H](C([C@@H](OC(C[C@@H]1O)=O)C(C)C)=O)C)=O)CC(C)C)N(CCC2)[C@]2([H])C(N([C@H](C(O[C@@H]([C@@H](C(N[C@]1([H])[C@@H](C)CC)=O)NC([C@@H](CC(C)C)N(C)C([C@H](CCC3)N3C([C@@H](O)C)=O)=O)=O)C)=O)CC(C=C4)=CC=C4OC)C)=O

Molecular Formula

C57H89N7O15

Molecular Weight

1112.35

Precautions

H319, H400, H410

References & Citations

[1]Stewart JA, et al. A phase I clinical trial of didemnin B. Cancer. 1991;68 (12) :2550-2554.|[2]Li LH, Timmins LG, Wallace TL, Krueger WC, Prairie MD, Im WB. Mechanism of action of didemnin B, a depsipeptide from the sea. Cancer Lett. 1984;23 (3) :279-288. |[3]Grubb DR, Wolvetang EJ, Lawen A. Didemnin B induces cell death by apoptosis: the fastest induction of apoptosis ever described. Biochem Biophys Res Commun. 1995;215 (3) :1130-1136.