NAI-N3
NAI-N3 is a RNA acylation reagent that enables RNA purification. NAI-N3 is a dual-function SHAPE (selective 2-hydroxyl acylation and profiling experiment) probe (RNA structure probe and enrichment) [1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
[1612756-29-2]
UNSPSC
12352005
Hazard Statement
H242, H315, H319
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/NAI-N3.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 16.67 mg/mL
Smiles
O=C(C1=CC=CN=C1CN=[N+]=[N-])N2C=CN=C2
Molecular Formula
C10H8N6O
Molecular Weight
228.21
Precautions
H242, H315, H319
References & Citations
[1]Flynn RA, et al. Transcriptome-wide interrogation of RNA secondary structure in living cells with icSHAPE. Nat Protoc. 2016 Feb;11 (2) :273-90.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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