Thalidomide-O-amido-C6-NH2 (hydrochloride)
Thalidomide-O-amido-C6-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Product Specifications
CAS Number
[2376990-31-5]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-o-amido-c6-nh2-hydrochloride.html
Purity
99.32
Solubility
10 mM in DMSO
Smiles
O=C(COC1=CC=CC(C(N2C(C(N3)=O)CCC3=O)=O)=C1C2=O)NCCCCCCN.Cl
Molecular Formula
C21H27ClN4O6
Molecular Weight
466.92
Precautions
H315, H319, H320
References & Citations
[1]Bradner J, et al. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses. WO 2017024318 A1
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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