8-Epidiosbulbin E acetate

8-Epidiosbulbin E acetate, a furanoid, is abundant in Dioscorea bulbifera L.. 8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. 8-Epidiosbulbin E acetate induces liver injury in mice[1][2].

Product Specifications

CAS Number

[91095-48-6]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/8-epidiosbulbin-e-acetate.html

Purity

98.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(O[C@@H]1[C@@]([C@@](C(O2)=O)([H])C[C@@]2([H])C3)([H])[C@]3([H])[C@](C)(C[C@@H](C4=COC=C4)O5)[C@@](C5=O)([H])C1)=O

Molecular Formula

C21H24O7

Molecular Weight

388.41

Precautions

H315, H319

References & Citations

[1]Shriram V, et al. A potential plasmid-curing agent, 8-epidiosbulbin E acetate, from Dioscorea bulbifera L. against multidrug-resistant bacteria. Int J Antimicrob Agents. 2008 Nov;32 (5) :405-10.|[2]Lin D, et al. Role of Metabolic Activation in 8-Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid. Chem Res Toxicol. 2016 Mar 21;29 (3) :359-66.|[3]Shi W, et al. Metabolomic-transcriptomic landscape of 8-epidiosbulbin E acetate -a major diterpenoid lactone from Dioscorea bulbifera tuber induces hepatotoxicity. Food Chem Toxicol. 2020 Jan;135:110887.|[4]Lin D, et al. In vitro and in vivo studies of the metabolic activation of 8-epidiosbulbin E acetate[J]. Chemical Research in Toxicology, 2015, 28 (9) : 1737-1746.