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MTOR inhibitor WYE-23

MTOR inhibitor WYE-23 is a mTOR inhibitor, and IC50 is 0.45 nM. It is selective to PI3Kα and IC50 is 661 nM. mTOR inhibitor WYE-23 has antitumor activity[1][2].

Product Specifications

CAS Number

1062169-46-3

UNSPSC

12352005

Target

MTOR

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mtor-inhibitor-wye-23.html

Purity

99.24

Solubility

10 mM in DMSO

Smiles

O=C(N1CCC(N2N=CC3=C(N=C(N=C32)C4=CC=C(C=C4)NC(NC5CC5)=O)N6CCOCC6)CC1)OC

Molecular Formula

C26H32N8O4

Molecular Weight

520.58

References & Citations

[1]Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52 (16) :5013-6.|[2]Nikola P. Pavletich et al. mTOR CRYSTALS AND MODULATORS. WO2014176281A1.2014-10-30.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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