Cinnamyl Alcohol

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities[1].

Product Specifications

CAS Number

[104-54-1]

UNSPSC

12352005

Hazard Statement

H302, H317, H411

Target

Akt; AMPK; ERK; NO Synthase; Potassium Channel; PPAR; ROCK

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cinnamyl-alcohol.html

Purity

99.86

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC/C=C/C1=CC=CC=C1

Molecular Formula

C9H10O

Molecular Weight

134.18

Precautions

H302, H317, H411

References & Citations

[1]Hwang DI, et al. Cinnamyl Alcohol, the Bioactive Component of Chestnut Flower Absolute, Inhibits Adipocyte Differentiation in 3T3-L1 Cells by Downregulating Adipogenic Transcription Factors. Am J Chin Med. 2017;45 (4) :833-846.|[2]Choi YR, et al., Cinnamyl Alcohol Attenuates Adipogenesis in 3T3-L1 Cells by Arresting the Cell Cycle. Int J Mol Sci. 2024 Jan 5;25 (2) :693.|[3]Kang YH, et al., Cinnamyl alcohol attenuates vasoconstriction by activation of K⁺ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase. Exp Mol Med. 2012 Dec 31;44 (12) :749-55.|[4]Lee H S. Chemical composition of Cinnamomum cassia leaf oils and suppression effect of cinnamyl alcohol on nitric oxide synthase[J]. Journal of the Korean Society for Applied Biological Chemistry, 2009, 52: 480-485.|[5]Zou L, et al., The anti-inflammatory effects of cinnamyl alcohol on sepsis-induced mice via the NLRP3 inflammasome pathway. Ann Transl Med. 2022 Jan;10 (2) :48.