Kushenol E

Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7 µM and a Ki of 9.5 µM, has anti-tumor activity[1].

Product Specifications

CAS Number

[99119-72-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Indoleamine 2,3-Dioxygenase (IDO)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kushenol-e.html

Purity

96.0

Solubility

10 mM in DMSO

Smiles

O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=C(C/C=C(C)\C)C(O)=C(C/C=C(C)\C)C(O)=C13

Molecular Formula

C25H28O6

Molecular Weight

424.49

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kwon M, et al. Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity. J Enzyme Inhib Med Chem. 2019 Dec;34 (1) :1481-1488.